EUCTR2007-003666-17-GB进行中（未招募）不适用
The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial - ATACAS
niversity Hospitals Bristol NHS Foundation Trust0 个研究点目标入组 2,400 人开始时间: 2007年9月14日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2,400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •males and females 18 years and older.
- •written informed consent.
- •elective coronary artery surgery.
- •Patient at increaed risk of major complications, defined by any of:
- •left ventricular ejection fraction impairment
- •Concomitant valvular or aortic surgery
- •aneurysmectomy
- •repeat cardiac surgery
- •chronic obstructive airways disease
- •renal impairment creatinine clearance 24-45
- •pulmonary hypertension
- •peripheral vascular disease
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Poor English
- •Clinician preference for antifibrinolytic
- •urgent surgery for unstable symptoms
- •active peptic ulceration
- •allergy or contraindication to aspirin or tranexamic acid
- •aspirin therapy within 5 days of surgery
- •warfarin or clopidogril within 7 days of surgery
- •GIIb/IIIa antagonists within 24 hours
- •thrombocytopenia
- •severe renal impairment creatinine clearance <25
- •history of thromboembolic disease
研究者
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