Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- vertical dimension at baseline
研究概览
简要总结
This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.
详细描述
Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •maxillary premolar teeth requiring extraction
- •neighboring mesial and distal sound/restored teeth present
- •alveolar bone level (measured from periapical radiographs) more than 50% of the root length
- •age ranges from 25-55 years
排除标准
- •bony fenestration of the socket wall confirmed from CBCT scan
- •acute signs of infection
- •periodontally compromised teeth
- •absence of buccal plates
- •any systemic disease which may hinder the healing process
研究组 & 干预措施
test (PRF-CS)
After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and calcium sulfate was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique.
干预措施: platelet-rich fibrin and calcium sulfate (Combination Product)
control (PRF-X)
After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and xenograft (MinerOss® X) was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique.
干预措施: platelet-rich fibrin and xenograft (Combination Product)
结局指标
主要结局
vertical dimension at baseline
时间窗: before extraction
measurements were done on radiograph (CBCT) images
horizontal dimension at baseline
时间窗: before extraction
measurements were done on radiograph (CBCT) images
soft tissue level at baseline
时间窗: before extraction
measurements were done on stone models
volume at baseline
时间窗: before extraction
measurements were done on radiograph (CBCT) images
次要结局
- horizontal dimension after extraction(five months after extraction)
- vertical dimension after extraction(five months after extraction)
- soft tissue level after extraction(five months after extraction)
- volume after extraction(five months after extraction)
研究者
Dr CHEAH CHIA WEI
Principal Investigator
University of Malaya