Physiologic MR Imaging in Distinguishing Benign From Malignant Salivary Gland Tumors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Differentiation and Progression Free
研究概览
简要总结
The goal of this study is to use advanced Magnetic Resonance Imaging (MRI) techniques to help identify the difference between cancerous and non-cancerous salivary gland tumors for improving treatment strategies and to aid in the prediction of disease progression.
详细描述
The goal of this proposed study is to investigate the potential utility of combined analysis of parameters (Ktrans, ti and ADC) in discriminating benign from malignant salivary glands tumors (SGTs). A total of 30 treatment naïve patients suspicious of SGT as observed on clinical evaluation and prior routine CT, MRI, Ultrasound, FNAC and/or PET will undergo 3T MRI. The MRI protocol will include acquisition of anatomical images with and without contrast agent injection, diffusion imaging and dynamic contrast enhanced-MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Possess a salivary gland lesion of 1cm3 size
- •Have no prior history of treatment for salivary gland lesion
排除标准
- •Has any prior history of cancer other than SGT
- •Has any MRI contra-indications
- •Has a history of known renal disease.
- •Has history of prior radiation to head and neck region
- •Is pregnant
结局指标
主要结局
Differentiation and Progression Free
时间窗: 6 Month after the end of treatment
Differentiation of malignant from benign neoplasms and progression free survival at 6 month starting from end of chemo-radiation treatment
次要结局
未报告次要终点
研究者
Sanjeev Chawla
Assistant Research Professor of Radiology
University of Pennsylvania