A Comparative Study on Outcomes of ABO-Incompatible Kidney Transplants Between Robot-Assisted vs. Open Surgery: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 239
- 试验地点
- 1
- 主要终点
- renal function
研究概览
简要总结
While robot-assisted kidney transplantation (RAKT) offers potential benefits such as minimal postoperative pain, better cosmesis, fewer wound infections, and shorter hospital stay, its efficacy in ABO-incompatible (ABO-i) KT compared to open KT (OKT) remains understudied. This study aims to compare ABO-i KT outcomes between RAKT and OKT.
The study utilized data from 29 ABO-i RAKT and 210 ABO-i OKT cases performed at Asan Medical Center from October 2020 to February 2023. Univariate and multivariate analyses were performed to evaluate factors associated with a composite of biopsy-proven acute rejection (BPAR), de novo donor-specific antibodies (DSA), and overall graft failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient eligible for living donor ABO incompatible kidney transplantation
- •Presenting an IsoAgglutinin immunoglobulin G titer (anti-A-B) between 1/8 and 1/128 before operation
- •Patient older than 18 years and young than 80 years
- •Patient able to sign an informed consent form
排除标准
- •Patient with comorbidities or hypersensitivity that prevent desensitization protocols
- •Women who are pregnant, or who may become pregnant or breastfeeding women
- •Subjects under legal protection
- •Subjects participating in another interventional research protocol or in an exclusion period from another interventional research protocolPatient affiliated with a social security scheme
结局指标
主要结局
renal function
时间窗: 1 year post-operative
renal function measured in terms of eGFR (Estimated Glomerular Filtration Rate)
Graft survival
时间窗: 1 year post-operative
allograft (kidney) survival
次要结局
- . A composite of biopsy-proven acute rejection, graft failure, and the development of de novo donor-specific antibodies(1 year post-operative)
研究者
Sei Won Lee
Clinical Professor
Asan Medical Center