NCT04917276尚未招募不适用
Treatment Response Prediction System of Metastatic Colorectal Cancer Based on Circulating Tumor Cells
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Specificity
研究概览
简要总结
This study enrolling patients with metastatic colorectal cancer. Detecting CTC at different points in the treatment process. Descripting the molecular atlas of CTC in mCRC patients. Building and validating a response prediction system of mCTC patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-80 years;
- •histologically proven colorectal liver metastasis
- •With liver-dominant disease (extrahepatic metastases limited to lung metastases)
- •A life expectancy of ≥ 3 months
- •Adequate hematologic function: absolute neutrophil count (ANC)≥1.5×109/l, platelets≥75×109/l, and international normalized ratio (INR) ≤1.3
- •Adequate liver and renal function: total bilirubin ≤2.0 mg/dl, alanine aminotransferase, aspartate aminotransferase ≤ 5x upper limit of normal, and albumin≥2.5 g/dl, serum creatinine≤2.0 mg/dl
- •Written informed consent for participation in the trial.
排除标准
- •Other previous malignancy within 5 years
- •Have metastases other than liver and lung metastases
- •Receiving any treatment before first blood collection
结局指标
主要结局
Specificity
时间窗: 1 year
The specificity of the response prediction model
Sensitivity
时间窗: 1 year
The sensitivity of the response prediction model
次要结局
未报告次要终点
研究者
相似试验
终止
不适用
Treatment Monitoring of Advanced Colorectal Cancer With 18F-FDG PET/CTColorectal CancerNCT00823810Turku University Hospital20
已完成
不适用
Colorectal Cancer Umbrella Protocol - Assessment of Targeted Therapies Against Colorectal Cancer (ATTACC Program) Screening ProtocolColorectal CancerNCT01196130M.D. Anderson Cancer Center1,275
已完成
不适用
Primary Tumour Response to Induction Chemotherapy in Synchronously Metastasized Colorectal CancerGastrointestinal NeoplasmNCT05172635Klinik Favoriten100
Unknown
不适用
Maintenance Chemotherapy for Metastatic Colorectal Carcinoma and Biological MarkerMetastatic Colorectal CancerNCT02043821Beijing Chao Yang Hospital80
Unknown
不适用
Metastatic Colorectal Cancer DatabaseMetastatic Colorectal CancerNCT04031625Centre Georges Francois Leclerc1,000