The Application of the New Magnetic Resonance Technique-UTE in Thoracic Lesions
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- T2 relaxation rate
研究概览
简要总结
Quantitative characteristic values of lung lesions were obtained by UTE technique, so as to make qualitative diagnosis of benign and malignant lesions. And to explore the clinical feasibility of CT-like technology - high resolution ZTE technology in the diagnosis of pulmonary diseases.
详细描述
Ultrashort echo time (UTE) sequence can obtain data from T2* for lung imaging before T2* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional MRI cannot clearly display short T2 tissue imaging, and can provide more supplementary information for lung CT scan. There has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. The 3D UTE sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung MR Images, and has successfully obtained submillimeter high-resolution images. The purpose of this study was to explore the value of MRI ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of CT-like technology - high resolution ZTE technology in the lung.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old;
- •There are lung lesions, and the solid component is ≥6mm;
- •Chest CT plain scan or /+ enhanced examination within 4 weeks.
排除标准
- •There are metal implants in the corresponding parts of the chest;
- •MRI contrast agent allergy;
- •Claustrophobia;
- •Pregnant women;
- •High fever;
- •Respiratory failure;
- •Lung lesion biopsy within 4 weeks prior to examination.
结局指标
主要结局
T2 relaxation rate
时间窗: baseline (before surgery)
R2\*
Magnetization Transfer Ratio (MTR)
时间窗: baseline (before surgery)
Magnetization Transfer Ratio
proton density fat fraction (PDFF)
时间窗: baseline (before surgery)
Determination of proton density fat fraction by magnetic resonance imaging
次要结局
- Subjective rating(baseline (before surgery))