Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 2
- 主要终点
- Define change from baseline levels of HIF-1 concentration and 3 of its regulated proteins after 6 months of quercetin (versus placebo) dietary intake.
研究概览
简要总结
The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers between the ages of 18-75 years old
排除标准
- •subjects taking vasoactive medications
- •hypertension or vascular disease
- •pregnant women
- •diabetes mellitus
- •history of seizures
- •history of stroke or head trauma
- •subjects taking digoxin, cyclosporine,felodipine, estradiol, or quinolone antibiotics
- •poor transcranial Doppler insonation windows
结局指标
主要结局
Define change from baseline levels of HIF-1 concentration and 3 of its regulated proteins after 6 months of quercetin (versus placebo) dietary intake.
时间窗: 6 months
Baseline and 6 month blood samples will be analyzed for levels of HIF-1, VEGF, EPO, and NOS
Determine change from baseline brain blood flow after 6 months of quercetin (versus placebo) dietary intake.
时间窗: 6 months
Determine cerebral vasomotor reactivity response to 6 months of quercetin intake by measuring changes in middle cerebral artery (MCA) blood flow velocity in response to changes in end-tidal CO2, and assess neurovascular coupling by measuring changes in MCA flow velocity in response to neuropsychological tasks.
次要结局
- Define change from baseline performance in a battery of cognitive tasks after 6 months of quercetin (versus placebo) dietary intake.(6 months)
研究者
Farzaneh Sorond
Principle Investigator
Brigham and Women's Hospital