NL-OMON42676招募中4 期
Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy? - LiO
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Subjects with stage II to IV colorectal adenocarcinoma, who are scheduled to receive 6-8 cycles of oxaliplatin 130 mg/m2 every 3 weeks.
排除标准
- •Receiving other chemotherapeutics in medical history
- •Allergy to amide type of local anesthetics
- •Recent myocardial ischemia (<6 months)
- •Cardiale arrhytmias
- •Renal function disorders (MDRD < 60)
- •Liver failure (bilirubine >1,5x upper limit of normal)
- •Adequate hematologic parameters
- •Hypokaliemia
- •Pregnancy or lactating
- •Use of anti-arythmic drugs (flecainide)
- •Pre-existing form of neuropathy (polyneuropathy or small fibre neuropathy)
- •History of chronic pain and opioid use
- •Risk factors for CIPN: alcoholism, diabetes mellitus
- •No written informed consent by patient
研究者
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