Effect of Acetazolamide in Prevention of Contrast Nephropathy
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Increased base line creatinine at least 25%
研究概览
简要总结
The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy
详细描述
Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patient that underwent coronary angiography
排除标准
- •serum Cr. more than 3 mg/dl
- •electrolyte and acid-base imbalance
- •pulmonary edema
- •allergy to Acetazolamide
研究组 & 干预措施
1
150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography
干预措施: sodium bicarbonate (Drug)
2
Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography
干预措施: Acetazolamide (Drug)
3
normal salin 1cc/kg/hr before and after angiography
干预措施: normal salin (Drug)
结局指标
主要结局
Increased base line creatinine at least 25%
时间窗: 24 hr later
次要结局
未报告次要终点