NCT00819871已完成不适用
Association of NFKB1 -94 Polymorphism With Lung and/or Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- lung injury and/or kidney injury after cardiac surgery with cardiopulmonary bypass
研究概览
简要总结
NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chinese Han unrelated population
- •undergoing elective cardiac surgery with CPB
排除标准
- •malignant tumor
- •autoimmune disease, immunodeficiency or immunosuppressive therapy
- •chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A)
- •COPD, tuberculosis or other chronic pulmonary diseases
- •anemia with hemoglobin lower than 90mmHg
- •bleeding disorders
- •postoperative pericardial tamponade requiring re-operation
- •postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.
结局指标
主要结局
lung injury and/or kidney injury after cardiac surgery with cardiopulmonary bypass
时间窗: 24h after cardiac surgery
次要结局
- circulating level of CRP, TNF-alpha, IL-10; APACHE Ⅱ score; duration of ICU stay and hospitalization; death in 28 days(one month after cardiac surgery)
研究者
研究点 (1)
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