The Effect of Inflammation on Bone Cells - The Effect of Inflammation on Bone Cells

Vrije Universiteit Medisch Centrum0 个研究点目标入组 55 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

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•1. Men and women between the age of 18 and 50 years
•2. Informed consent
•3a. Patients suffering from Crohn*s disease of at least 3 months duration, confirmed by
•radiography, endoscopy and histology (according to the Lennard-Jones criteria ; Lennard-Jones 1989).
•3b. Patients suffering from Ulcerative Colitis of at least 3 months duration, confirmed by
•radiography, endoscopy and histology (according to the Lennard-Jones criteria)
•4. a BMI between 18-30

•1. Co-morbidity influencing bone metabolism
•- Renal insufficiency (creatinin clearance < 40 ml/min)
•- untreated hypo- / hyperthyroidism (stabily treated hypothyroidism may be included)
•- Paget*s disease or other metabolic bone diseases, Cushing*s disease or hyperprolactinemia
•2. Patients who have received calcitonin, bisphosphonates and strontium within 1 year
•3. Use of corticosteroids current use and in the last 3 months in case of longterm use or in the last 6 weeks in case of induction therapy
•4. Patients who have been treated with anti-TNF in the last 6 months
•5. Use of antitrombotic agents
•6. Patients who are pregnant, breast-feeding or menopausal

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