Evaluation of Comparative Efficacy of a Personalized Physiotherapy Protocol Stratified by Apraxia Subtype and Lesion Location Versus Standard Care in Management of Post-Stroke Limb Apraxia: A Randomized Controlled Trial

Anshu Tikariha1 个研究点分布在 1 个国家目标入组 96 人开始时间: 2026年3月16日最近更新: 2026年2月24日

试验速览

阶段: 不适用
状态: 尚未招募
发起方
入组人数: 96
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

This randomized, double-blind, parallel-group trial compares a personalized physiotherapy protocol stratified by apraxia subtype and lesion location with standard physiotherapy care in patients with post-stroke limb apraxia. Ninety-six participants will be randomized (1:1) to receive either personalized or conventional rehabilitation, five sessions per week for six weeks. Primary outcomes include functional independence (Barthel Index, FIM) and motor planning accuracy assessed using kinematic parameters, while quality of life (SIS16) is a secondary outcome. The study hypothesizes that stratified, lesion-informed physiotherapy will produce superior clinical improvement compared to standard care.

研究设计

研究类型: Interventional
分配方式: Randomized
盲法: Participant and Outcome Assessor Blinded

入排标准

年龄范围: 40.00 Year(s) 至 65.00 Year(s)（—）
性别: All

入选标准

•First ever stroke with left-sided unilateral vascular lesion, confirmed via neuroimaging within 3 to 6 months of stroke.
•Right handed individuals, as determined by Briggs and Nebes Laterality Inventory, to control for hemispheric dominance in praxis processing.
•Cognitive function within normal range, indicated by a Mini-Mental State Examination (MMSE) score more than 23
•Presence of limb apraxia, confirmed by Van Heugten Apraxia Test with a score less than
•For IA, the De Renzi Test for IA score is between 0 to 14 and for IMA, the De Renzi Test for IMA score is between 0 to
•Score between 0 and 3 on the Modified Rankin Scale (mRS) that is mild to moderately severe post-stroke disability
•Spasticity graded less than 2 according to the Modified Ashworth Scale and Brunnstrom stage 4 and above.
•Age between 40 and 65 years.

排除标准

•Presence of neurodegenerative disorders like Parkinsons disease, dementia, Alzheimers and severe cognitive impairment.
•2.Severe aphasia using Aphasia Severity Rating, ASR, more than or equal to
•3.Previous history of other neurological disorders, a known intellectual or learning disorder
•Severe comorbid medical conditions or debilitating chronic disease like chronic liver disease or chronic kidney disease, limiting participation in rehabilitation.

研究者

发起方

Anshu Tikariha

申办方类型

Other [self]

责任方

Principal Investigator

主要研究者

Anshu Tikariha

Department of Neurophysiotherapy

研究点 (1)

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