Evaluation of the Healthy Lifestyle Program on Cognitive Outcomes

Change in body mass index (BMI) in kg/m^2

时间窗: Baseline and 17 weeks

Change in body mass index (BMI) in kg/m\^2

Change in subject executive function

时间窗: Baseline and 17 weeks

Stroop test is used to assess executive function. Higher score indicates better performance. Raw score range: 0-300.

Change in Brief Visuospatial Memory Test-Revised (BVMT-R)

时间窗: Baseline and 17 weeks

BVMT-R is used to evaluate spatial memory ability. Scores range from 0 to 60, with higher values indicating better performance.

Change from baseline Anxiety Symptoms at 17 weeks

时间窗: Baseline and 17 weeks

will be assessed using the Generalized Anxiety Disorder-7 (GAD7). The GAD7 scores range from 5-21, with 5-9 indicating mild, 10-14 moderate, and greater than 15 severe anxiety.

Change from baseline Subjective Health Status (PROMIS) at 17 weeks

时间窗: Baseline and 17 weeks

Patient Reported Outcomes Measurement Information Systems (PROMIS) Global Short Form. PROMIS is a 10-item instrument capturing physical, mental and social aspects of quality of life having undergone quantitative appraisal and is non-proprietary. Higher score indicated more positive perceptions of overall health.

Change in Prospective and Retrospective Memory Questionnaire (PRMQ)

时间窗: Baseline and 17 weeks

PRMQ is a questionnaire about daily memory difficulties. Higher scores represent worse outcomes. Total score ranges from 0-64.

Change in grip strength

时间窗: Baseline and 17 weeks

Assessed by a Jamar dynamometer. Sensor-based Thera-bands will measure data on strength change. A higher score represents a better outcome.

Change in weight in kg

时间窗: Baseline and 17 weeks

Change in weight in kg

Change in subject cognition

时间窗: Baseline and 17 weeks

Verbal fluency test is used to evaluate language function. Performance will be identified via the total number of appropriate words responded on each of the task. Higher score indicates better performance.

Change in speed processing

时间窗: Baseline and 17 weeks

Trail making Test-A\&B is used to assess information processing speed. Shorter time indicates better performance.

Change in subject memory

时间窗: Baseline and 17 weeks

California Verbal Learning Test II (CVLT-II) Trials 1-5 Total raw score (range: 0-80; higher values represent a better outcome)

Change in 5 times Sit-to-Stand (STS)

时间窗: Baseline and 17 weeks

STS measures lower limb strength (minimal change 2.3 s). A higher score represents a better outcome.

Change from baseline Mood Symptoms at 17 weeks

时间窗: Baseline and 17 weeks

Will be assessed using the Patient Healthy Questionnaire (PHQ9). The PHQ9 scores range from 0-27, with lower numbers indicating minimal to no depression and higher numbers indicating severe depression.

Change in Six-Minute Walk Test (6MWT)

时间窗: Baseline and 17 weeks

A surrogate for cardiovascular fitness that measures distance (normal 400-700m) related to function. A clinically important difference is 50-55m

Change in subject processing speed

时间窗: Baseline and 17 weeks

Single Digit Modalities Test: Measure of cognition/processing speed. Score range 0 to 110. A higher score represents a better outcome.

Change in language function

时间窗: Baseline and 17 weeks

Boston Naming Test (BNT) is used to evaluate language function. Score range:0-42; higher score indicates better performance.

Change in Behavior Rating Inventory of Executive Function (BRIEF-A)

时间窗: Baseline and 17 weeks

Behavior Rating Inventory of Executive Function (BREIF-A) is used to evaluate executive functioning.This questionnaire consist of 75 items on which the patient's symptoms are rated on a 3-point Likert scale. The questionnaire provides a Global Executive Composite score (range 75-225) and two index scores: the Behavioral Regulation Index (range 30-90) and the Metacognitive Index (range 40-120) in addition to nine subscales: Inhibit (range 8-24), Shift (range 6-18), Emotional control (range 10-30), Self-monitor (range 6-18), Initiate (range 8-24), Working memory (range 8-24), Plan/organize (range 10-30), Task monitor (range 6-18) and Organization of materials (range 8-24). Higher scores indicate more executive difficulties.