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临床试验/NCT06771349
NCT06771349已完成不适用

Assessment of Recurrence Rate After Sigmoidopexy for Acute Sigmoid Volvulus

West China Hospital1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2023年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
70
试验地点
1
主要终点
To determine the recurrence rate of SV following sigmoidopexy or sigmoidectomy.

研究概览

简要总结

Colonic volvulus, where part of the colon twists, is a significant cause of large bowel obstruction, representing 15% of cases, second only to cancer and diverticulitis. Acute sigmoid volvulus (SV), which affects the sigmoid colon, is the most common type, with morbidity rates ranging from 6% to 42% and mortality varying from 7% to 90%. The incidence of SV varies globally, being more common in regions such as Africa, Ethiopia, Australia, and East Asia, where it can account for up to 50% of bowel obstructions.

SV often presents as partial or complete obstruction and can lead to severe complications such as ischemia, necrosis, and perforation, especially in older patients. The primary treatment goals are relieving the obstruction, reducing pressure, and correcting the twist. According to the World Society of Emergency Surgery (WSES), endoscopic decompression is recommended for patients without infection, perforation, or hemodynamic instability. However, surgery is necessary if decompression fails, with options including sigmoidopexy, sigmoidectomy, or colostomy. Sigmoidopexy is less invasive but has a higher recurrence rate, while sigmoidectomy, though riskier, may reduce recurrence and improve long-term survival.

This retrospective study aims to compare the outcomes of sigmoidopexy and sigmoidectomy in patients with acute SV undergoing emergency surgery at West China Hospital, Sichuan University, over a 14-year period. The primary outcome is the recurrence rate of SV, with secondary outcomes including 30-day mortality and morbidity (complications).

详细描述

Introduction:

Colonic volvulus, a significant cause of large bowel obstruction, occurs when a segment of the colon twists, obstructing normal bowel function. Among the different types of colonic volvulus, acute sigmoid volvulus (SV) is the most common, with a high incidence in certain regions, such as the "twist belt" in Africa, Ethiopia, East Asia, and Australia, where its frequency can exceed 50%. SV frequently presents as either partial or complete bowel obstruction, leading to ischemia, necrosis, and potential perforation if untreated. The morbidity and mortality associated with SV are substantial, particularly in elderly patients. Prompt management is crucial to reduce complications and improve patient outcomes.

Treatment Approaches:

The primary goal of treatment is to relieve the obstruction and address the twisted portion of the colon. The World Society of Emergency Surgery (WSES) recommends endoscopic decompression for patients without signs of severe infection, perforation, or hemodynamic instability. If decompression fails, or if necrosis is present, surgical intervention is necessary. Surgical options include sigmoidopexy, sigmoidectomy, mesenteroplasty, or colostomy. Sigmoidopexy is less invasive but carries a higher risk of recurrence, whereas sigmoidectomy, though more complex, may reduce recurrence and improve long-term survival.

Despite various treatment options, the optimal approach remains unclear due to inconsistencies in the existing literature. This study compares two commonly used surgical methods-sigmoidopexy and sigmoidectomy-to assess their outcomes in terms of SV recurrence, complications, and overall survival.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients presenting with symptoms of acute intestinal obstruction.
  • Diagnosis of acute SV confirmed by the typical "whirl sign" on computed tomography (CT) or laparotomy.
  • First emergency surgery for acute SV performed at our institution.

排除标准

  • Torsion of intestinal segments other than the sigmoid.
  • Patients diagnosed with "acute SV" but treated conservatively or operated on at another hospital.
  • Concurrent conditions such as non-SV-related bowel perforation or obstruction.
  • Patients with severe overall states not amenable to surgery.

结局指标

主要结局

To determine the recurrence rate of SV following sigmoidopexy or sigmoidectomy.

时间窗: between April 2009 and August 2023

The recurrence rate is the number of cases in which a patient has a recurrent torsion of the sigmoid colon after surgical treatment, as a proportion of all patients who undergo surgical treatment, and is usually calculated by the following equation: Recurrence rate = the number of patients with recurrence of sigmoid volvulus after surgery /the total number of patients who underwent surgery ×100%

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Xiaomei Jiang

Resident Physician

Sichuan University

研究点 (1)

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