Obesity and Muscle Function Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Muscle Fiber
研究概览
简要总结
This pilot study is designed to determine the relationship between intra-myocellular lipids and muscle contractility in fibers from obese and non-obese older adults. Obese participants are being recruited for an on-going weight loss intervention study and this application seeks approval to recruit and enroll a lean comparison group of non-obese older adults. The primary goal of this study is to characterize the contractile properties of single muscle fibers and whole muscle in healthy, non-obese individuals under the same recording conditions the investigators used for the obese population to begin to determine whether fat infiltration accounts for diminished force.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age=65-75 years
- •BMI=18-24 kg/m2
- •No resistance training for past 6 months
- •Normal cognitive function (MMSE >24)
- •No contraindications for participation in weight loss or weight lifting exercise including severe arthritis or musculoskeletal disorders, knee or hip replacement or spinal surgery in past year
- •Able to provide own transportation to study visits
- •Not involved in any other research study involving strength training or undergoing physical therapy
- •Not dependent on a cane or walker
- •Willing to provide informed consent
排除标准
- •Weight loss or gain (±5%) in past 6 months
- •Body mass >136 kg (DXA limit)
- •Current smoker (No nicotine within past year) or evidence of alcohol or drug abuse
- •Insulin dependent or uncontrolled diabetes (FBG >140 mg/dL)
- •Uncontrolled hypertension (BP>180/100 mmHg)
- •Abnormal kidney function or liver blood tests
- •Serious conduction disorder (e.g., 3rd degree heart block), uncontrolled arrhythmia, or new Q waves or ST-segment depressions (>2 mm) on ECG
- •Past or current cardiovascular disease, including uncontrolled angina or dysrhythmia, hypertrophic cardiomyopathy, congestive heart failure, PAD, stroke, history of myocardial infarction, use of defibrillator or major heart surgery, or deep vein thrombosis or pulmonary embolus. These will be reviewed on a case by case basis.
- •Past or current respiratory disease (requiring steroid treatment or supplemental oxygen)
- •Past or current clinical diagnoses of neurological or hematological disease
- •Use of any medications that could influence study variables (growth/steroid hormones, prescription anti-inflammatory medications, or beta blockers, Coumadin or any other blood thinner, including Plavix, Ticid, and Aggrenox)
- •Cancer requiring treatment in past 2 years, except non-melanoma skin cancers
- •Clinically evident edema or anemia
结局指标
主要结局
Muscle Fiber
时间窗: Baseline
Primary Aim: To measure single muscle fiber contractile properties, including specific force, unloaded shortening velocity, and maximum power. We will also measure whole muscle strength and size and fiber fat infiltration. These results will establish a reference database against which data recorded in older obese individuals can be compared. Primary hypothesis: Single muscle fibers will exhibit more force and power in healthy non-obese than obese older adults due to greater intra-myocellular fat infiltration.
次要结局
- Muscle Strength(Baseline)
研究者
Barbara Nicklas, PhD
Professor
Wake Forest University Health Sciences