SsST Segment Resolution After Primary Percutaneous Coronary Intervention. A Comparison Between Primary Percutaneous Coronary Intervention With and Without Thrombus Aspiration
试验速览
- 阶段
- 不适用
- 入组人数
- 270
- 主要终点
- ST segment resolution
研究概览
简要总结
To compare the ST segment resolution after primary percutaneous coronary intervention (PPCI) with and without thrombus aspiration in patients with ST segment elevation myocardial infarction as ST segment resolution is the best indicator for the prediction of the outcome and MACE
详细描述
The idea of an occluding thrombus and its dissolution had been stated since the 1950s.1 Thrombus is present in the infarct-related artery in 88% of patients undergoing coronary artery angiography within the first 4 h of acute myocardial infarction (AMI).
The finding of ST segment elevation in a patient presenting with chest pain allows rapid identification of those who benefit from emergency reperfusion.
Primary percutaneous coronary intervention (PPCI) is now the preferred strategy for emergency reperfusion in patients presenting with ST elevation myocardial infarction (STEMI).
Thrombus aspiration (TA) might be an effective procedure for reducing distal embolization and improving microvascular perfusion in ST-segment elevation myocardial infarction (STEMI), especially in patients with high thrombus burden.
Despite the class III recommendation for routine Thrombus Aspiration use before balloon angioplasty or stenting. manual Thrombus Aspiration might still remain a useful strategy for the interventional cardiologist when treating selected patients with significant thrombus burden during PPCI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •. patients with STEMI within 24 hours of chest pain.patients killip class 1 is included in this study
- •xclusion Criteria:
- •killip II-IV
- •Previous myocardial infarction
- •Patients with left bundle branch block
- •Patients with advanced cancer disease
- •Patients qith contraindications to anti-coagulation
- •Patients with sensitivity to clopidogrel
排除标准
- 未提供
结局指标
主要结局
ST segment resolution
时间窗: Within 90 minutes after the procedure
ST segment resolution in relation to the procedure used in primary percutaneous coronary intervention
次要结局
- MACE(one week)
研究者
Amany Ragab Abdel mageed
Principal investigator
Assiut University