Female Sexual Dysfunctions in Patients With Chronic Renal Failure
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 主要终点
- effect of chronic renal failure in females on their sexuality function
研究概览
简要总结
A myriad of sexual problems affect men and women with chronic kidney disease (CKD), including decreased libido, erectile dysfunction, dysmenorrhea, and infertility. Menstrual abnormalities are common in CKD and many women are an-ovulatory .
Causes of sexual dysfunction in CKD include hormonal alterations along with vascular, neurologic, psychogenic, and other factors, such as medications, contribute to the development of sexual dysfunction . Sexual dysfunction in females is mainly due to hormonal factors and manifests mainly as menstrual irregularities, amenorrhea, lack of vaginal lubrication, and failure to conceive.
详细描述
Hormonal changes in chronic kidney disease are seen in prolactine, gonadotropins, and gonadal hormones. In women with CKD, elevated levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are common. These hormonal changes are detected in the early stages of kidney disease and progressively worsen as kidney disease progresse .
. Women with chronic renal failure commonly have elevated circulating prolactin levels. As in men with chronic renal failure, the hypersecretion of prolactin in this setting appears to be autonomous, as it is resistant to maneuvers designed to stimulate or inhibit its release.
It has been suggested that the elevated prolactin levels may impair hypothalamic-pituitary function and contribute to sexual dysfunction and galactorrhea in these patients. However, uremic women treated with bromocryptine rarely resume normal menses and continue to complain of galactorrhea (if present), despite normalization of the plasma prolactin concentration. Thus, factors other than hyperprolactinemia must be important in this setting .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •-Female patients with chronic renal failure (eGFR <15 ml/min/1.7m2 ) on dialysis or not.
- •Age from 18 to 45 years old.
- •Sexually active during the last 6 monthes.
排除标准
- •Pregnant women.
- •Other medical diseases ( diabetes mellitus ,cardiac disorders ,neurological disorders and other systematic diseases).
- •Taking medications affect sexuality function e.g. antidepressant drugs.
结局指标
主要结局
effect of chronic renal failure in females on their sexuality function
时间窗: two years
compare sexuality function between female with chronic renal failure and normal female and observe difference between two groups
次要结局
未报告次要终点
研究者
Esraa Ahmed Mohamed
GP
Assiut University