Effect of Qishen Huoxue Granules on coagulopathy/early DIC in sepsis and its mechanism

Beijing Friendship Hospital, Capital Medical University0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•Adults >= 18 years old, meet SEPSIS 3.0 diagnostic criteria and have coagulopathy/early DIC. 1) Sepsis inclusion criteria, according to SEPSIS 3.0 diagnostic criteria. 2) Coagulation disorders/early DIC, refer to the International Society of Thrombosis and Hemostasis DIC scoring system (ISTH) for diagnosis. DIC scores of 3 to 4 are included.

•1) Pregnant or breastfeeding women;
•2) Aged < 18 years;
•3) Platelets < 30,000/L;
•4) Patient has life-threatening active bleeding;
•5) 12 hours before and after major surgery on chest, abdomen, skull, peripheral blood vessels and other parts Internal;
•6) a history of severe brain injury and intracranial surgery;
•7) intracranial vascular malformations, cerebral hemangioma, large central central lesions and stroke within three months;
•8) hemophilia and other congenital coagulation diseases;
•9) The patients previous severe liver cirrhosis, esophageal varices or bleeding history and current ascites;
•10) Severe gastrointestinal, respiratory, urinary tract bleeding, gastrointestinal leakage; a history of gastrointestinal, urinary tract bleeding within 6 weeks Hemorrhage in the tract or respiratory tract requires special treatment;
•11) have used aspirin > 650 mg/d or warfarin in the past 7 days, or have undergone thrombolytic therapy in the past 1 month;
•12) the patient is dying (estimated Died within 6 hours);
•13) Known or suspected brain death;
•14) Is undergoing dialysis treatment;
•15) The patient is undergoing other treatment studies that may interfere with this study.

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