Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 2
- 主要终点
- Experiment1: Identification of the best characteristics that allow us to create a backward masking effect of the second stimulus on the first one.
研究概览
简要总结
Background:
'Free will' can be defined as the belief that people have control over their thoughts and movements. The topic of free will is controversial and is still being debated. Science has only partial answers to questions about free will, so researchers want to learn more about it. They want to assess the role of consciousness when intentions are present with behavior. This could help to explain the causal role of consciousness in movement or decisions.
Objective:
To learn more about free will.
Eligibility:
Healthy, right-handed adults ages 25-45
Design:
Participants will be screened with medical history, physical exam, and neurological exam.
Participants will have 1 study visit. It will last up to 4 hours.
Participants will sit in a comfortable chair in front of a screen. They will perform some or all of the following tasks.
Visual Task. Participants will watch different stimuli on the screen and answer simple questions.
Electroencephalography (EEG). An EEG records the electrical activity of the brain ('brain waves'). For the EEG, small electrodes are put on the scalp with an electrode cap. A gel is placed in the space between the electrodes and the scalp. Participants' brain waves will be recorded, including while they decide whether to move their thumb.
Choice/Reaction Time Task. Participants will watch different stimuli on the screen and react to them by moving their wrist. During this task, they will wear an EEG cap on their head and electrodes on their arms and wrists.
Electromyography. Small electrodes will be attached to participants' skin. Their muscle activity will be recorded while they decide whether to move their wrist and during the movement itself.
Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive brain stimulation that uses magnetic field to stimulate nerve cells in your brain. TMS can increase or decrease brain activity in particular area of your brain. TMS operates completely outside of the body and is generally very well tolerated....
详细描述
Study Description:
The main focus of this protocol will be to try to identify the quale of free will, its electrophysiological correlates, and to determine whether this quale plays a causative role in movement.
Objectives:
Primary Objectives:
We will be doing a series of experiments. In the first experiments, we want to explore the behavioral response of normal subjects when they move after a visual stimulus that can be seen or unseen. We want to study behavior in different conditions with movement triggered by stimuli that are seen and not seen. Furthermore, we want to analyze the EEG related to those stimuli to explore sensory and motor processing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Experiment1: Identification of the best characteristics that allow us to create a backward masking effect of the second stimulus on the first one.
时间窗: throughout
We will develop a methodological approach to create the best backward masking effect. We will ask the subjects what they saw, to prove the effectiveness of the backward masking.
Experiment 2: Reaction time and accuracies of the responses to different stimuli (symbols, faces, objects, etc.) in different conditions (with and without masking)
时间窗: throughout
Subjects will move to the first stimulus even if unseen. We want to study subjects behavior in different conditions (simple reaction task, choice reaction task, with and without masking) with different stimuli (symbols, faces, objects, etc.). Furthermore, we want to analyze the EEG (classic ERP, microstates, etc.) related to those stimuli. EEG will be also analyzed to study the nature and strength of the visual pathway for movement and the pathway for visual perception at rest.
Experiment 1: Identification of the EEG characteristic or ERP shape related to different stimuli and the brain region origin.
时间窗: throughout
We will create a template of the shape of the ERP and the characteristics of EEG related to different stimuli to be identified in the second sub-study.
次要结局
未报告次要终点