Continuous Versus Intermittent Oxytocin for Induction of Labor: A Randomized Study
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- induction-to-delivery time
研究概览
简要总结
This study evaluates continuous oxytocin versus intermittent oxytocin for induction of labor at term. Half of participants will be taken continuous oxytocin, while the other half will be taken intermittent oxytocin.
详细描述
In the continuous oxytocin group, traditional treatment of oxytocin used at a starting dose of 1-2 mIU/min and the dose was increased by 2 mIU/min at every 15 minutes until regular contractions obtained at a rate of 3-5 contractions in a 10-minute period. The maximum dose of oxytocin was 40 mIU/min and oxytocin was administered until delivery. In the intermittent group, oxytocin was discontinued when cervical dilation was 5 cm and 2 hours after discontinuation oxytocin was reused at a starting dose of 1-2 mIU/min and was increased as the same protocol used for continuation oxytocin group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •singleton pregnancy,
- •37≤ weeks of gestational age ,
- •vertex presentation,
- •women with cervical dilation 3 cm
- •no contraindication to vaginal delivery.
排除标准
- •fetal malpresentation,
- •multifetal pregnancy,
- •more than three contractions in 10 minutes,
- •contraindications to oxytocin,
- •a category II or III fetal heart rate pattern,
- •fetal anomaly,
- •fetal demise
- •women with immediate delivery indications
研究组 & 干预措施
Continuous oxytocin
oxytocin will be used at a starting dose of 1-2 mIU/min and the dose will be increased by 2 mIU/min at every 15 minutes until regular contractions will be obtained at a rate of 3-5 contractions in a 10-minute period. The maximum dose of oxytocin will 40 mIU/min and oxytocin will be administered until delivery.
干预措施: Oxytocin (Drug)
intermittent oxytocin
oxytocin will be discontinued when cervical dilation will 5 cm and 2 hours after discontinuation oxytocin will be reused at a starting dose of 1-2 mIU/min and will be increased as the same protocol will be used for continuation oxytocin group.
干预措施: Oxytocin (Drug)
结局指标
主要结局
induction-to-delivery time
时间窗: intraoperative
次要结局
未报告次要终点
研究者
Ahmet Eser
medical doctor
Zeynep Kamil Maternity and Pediatric Research and Training Hospital