Does repeated administration of cefuroxime after orthopedic surgery provide a better prophylactic profile regarding postoperativ infection than a single administration of preoperative antimicrobial ? - A micro dialysis study assessing the concentration of antibiotics in bone, synovial sheath, and subcutaneous tissue after trapeziectomy - MANUS

Aarhus University Hospital0 个研究点目标入组 16 人开始时间: 2019年3月15日最近更新: 2021年8月17日

适应症

试验速览

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•- signed informed consent
•- age minimun 18 years
•- elective trapeziectomy at the Department of Orthopedic Surgery, Aarhus University Hospital
•- Normal liver- and kidney numbers
•- Fertile women have to use safe contraception. Fertile women, who do not use safe contraception will have to perform a urin-hCG.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 10
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 6

•- Allergy towards antibiotics from the group of beta-lactams (penicillins, cephalosporins, and carbapenems)
•- Diabetes
•- Previous surgery of the 1. metacarp (concerns the operated hand)
•- Previous fracture of the 1. metacarp (concerns the operated hand)
•- Previous surgery of the arteries in the arm (concerns the operated hand)
•- Treatment with cefuroxime 4 days prior to the surgery

发起方

Aarhus University Hospital