Working Memory Training to Decrease Depression, Anxiety and Rumination in Dysphoric Students
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Beck Depression Inventory Second Edition (BDI-II) score change between pre and post measurement
研究概览
简要总结
Depression is associated with impairments in executive functions, including working memory (WM) which is needed to maintain and manipulate goal-relevant information. Due to these WM impairments depressed individuals have difficulties inhibiting and shifting from irrelevant (negative) information and updating goal relevant information. This study explored whether training WM decreases these impairments and reduces clinical symptoms of depression, anxiety and rumination. Sixty-one students with an elevated score on the BDI-II, representing a dysphoric mood state, executed a working memory training (n = 34) or placebo training (n = 27). Before and after training their depression, anxiety, rumination and working memory were assessed. Furthermore, they executed a working memory task while their pupil dilation was measured to assess their fatigue. Moreover, the investigators compared the dysphoric students with a healthy student population on all measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 17 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BDI 10 of higher for dysphoric group
- •BDI 5 or lower for healthy control group
排除标准
- 未提供
研究组 & 干预措施
Working memory training
Participants executed the training for three weeks, three times a week, half an hour per session. The training was a game in which the participant was a person who had to become strong to fight with a fantasy figure. The person could become stronger when giving the right answers in eight different working memory tasks. The level adapted to the working memory capacity of the participant.
干预措施: Working memory training (Behavioral)
Placebo training
Participants executed the training for three weeks, three times a week, half an hour per session. The training was a game in which the participant was a person who had to become strong to fight with a fantasy figure. The person could become stronger when giving the right answers in eight different working memory tasks. The level in the placebo condition was easy and did not adapt to the working memory capacity of the participant.
干预措施: Placebo training (Behavioral)
结局指标
主要结局
Beck Depression Inventory Second Edition (BDI-II) score change between pre and post measurement
时间窗: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline)
Depression is measured with the BDI-II
次要结局
- State-Trait Anxiety Inventory (STAI) scores change from pre to post training measurement(Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline))
研究者
Ingmar Franken
Professor
Erasmus Medical Center