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临床试验/CTRI/2025/08/092791
CTRI/2025/08/092791尚未招募2/3 期

Pilot Study: Comparing the Duration of Action in Ultrasound-Guided Nerve Blocks with 10 Percentage Dextrose Versus Normal Saline Addition

Vinayaka Missions Medical College and Hospital1 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2025年8月25日最近更新:

试验速览

阶段
2/3 期
状态
尚未招募
发起方
入组人数
14
试验地点
1
主要终点
To assess and compare the duration of action in ultrasound-guided nerve blocks when using 10% dextrose as an additive versus normal saline

研究概览

简要总结

This pilot study investigates whether adding 10% dextrose to local anesthetics in ultrasound-guided peripheral nerve blocks offers longer and more effective pain relief compared to normal saline. Conducted at Vinayaka Missions Medical College & Hospital, Karaikal, over six months, the randomized study will include 14 patients divided into two groups of seven each. Group A will receive a combination of local anesthetics with 10% dextrose, while Group B will  receive the same anesthetics with normal saline. The study focused on comparing the duration of anesthesia, onset of pain relief, patient satisfaction, and safety profiles between the two groups. Sensory and motor blocks were assessed every 2–3 minutes post-injection, and pain levels were recorded using the Visual Analogue Scale. The study included patients aged 10–80 years undergoing orthopedic or wound-related limb surgeries, with exclusion criteria such as ASA IV status, allergies to anesthetics, and coagulopathies. Results aim to determine if 10% dextrose can enhance block duration, reduce the need for rescue analgesia, and improve overall patient outcomes in clinical anesthesia practice.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant Blinded

入排标准

年龄范围
10.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • ASA physical status 1,2 and
  • Patient undergoing orthopedic limb surgeries both upper limb and lower limb.
  • Patients undergoing surgical or orthopedic wound debridement.
  • Patients undergoing split skin graft over the extremities.

排除标准

  • Absolute contraindications to the use of peripheral nerve blocks such as allergy to local anesthetics, inability to cooperate, patient refusal.
  • Active infection at the injection site.
  • Pre-existing neural deficits along the distribution of the block.
  • Patients with coagulopathies.
  • Patients on antithrombotic drugs.

结局指标

主要结局

To assess and compare the duration of action in ultrasound-guided nerve blocks when using 10% dextrose as an additive versus normal saline

时间窗: 3 mins, 6 mins, 9 mins, 12 mins, 15 mins, 18 mins, 20 mins

次要结局

  • 1) To evaluate the onset of the analgesic effect in ultrasound-guided nerve blocks with 10% dextrose compared to normal saline.(2) To analyze the safety profile of the nerve blocks with 10% dextrose versus normal saline, considering any adverse events or complications.)

研究者

发起方
Vinayaka Missions Medical College and Hospital
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Prasanna Vadhanan

Vinayaka Missions Medical College and Hospital, Karaikal

研究点 (1)

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