NL-OMON21096招募中不适用
Effects of Acetate on Insulin Sensitivity, CNS regulation of food intake and appetite in Humans
Amsterdam University Medical Centersm location AMC0 个研究点目标入组 60 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
研究概览
简要总结
are planned end 2022
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Inclusion criteria healthy lean subject group:
- •- Healthy Caucasian male or female
- •- Age 40-65
- •- Women must be post-menopausal
- •- BMI range of 19-25 kg/m2
- •- Subjects should be able and willing to give informed consent.
- •Inclusion criteria obese metabolic syndrome subject group:
- •- Caucasian male or female with metabolic syndrome
- •- Age 40-65
- •- Women must be post-menopausal
- •- BMI range of 25-40 kg/m2
- •- At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose = 5.6 mmol/L and/or HOMA-IR = 2.5, triglycerides = 1.6 mmol/L, waist-circumference > 102 cm, HDL cholesterol = 1.04 mmol/L, blood pressure = 130/85.
- •- Subjects should be able and willing to give informed consent.
排除标准
- •Exclusion criteria for all participants
- •- Systemic medication use, except for paracetamol
- •- Oral or intravenous antibiotics in the past 3 months before inclusion
- •- Substance abuse
- •- Contra-indication for MRI, such as claustrophobia or pacemaker
研究者
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