NCT02829216Unknown不适用
Functional Profiling of the Hematopoietic Stem Cell Niche in Graft Versus Host Disease Mediated Bone Marrow Insufficiency
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Changes in the amount of mesenchymal stromal cells after allogeneic hematopoietic stem cell transplantation
研究概览
简要总结
The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation. Furthermore, the immune cell infiltrate of the bone marrow will be monitored at the same time. These results will be correlated with the extent of cytopenia and clinical graft-versus-host disease grading.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute myeloid leukemia
- •myelodysplastic syndrome
- •hematopoietic stem cell transplantation
排除标准
- •not willing to take part
结局指标
主要结局
Changes in the amount of mesenchymal stromal cells after allogeneic hematopoietic stem cell transplantation
时间窗: up to 1 year after allogeneic hematopoietic stem cell transplantation
次要结局
未报告次要终点
研究者
研究点 (1)
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