Quality of Life and Dynamic Visual Acuity in Patients With Bilateral Vestibulopathy: the Impact of Covert-saccades
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Frequency of covert-saccades
研究概览
简要总结
Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria
- •Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
- •Pathologic Head-impulse test
- •VOR gain of <0.25 on rotatory chair tests
- •Disorder present for over 6 month
- •Comprehension of the experiments instructions
- •Patient consent
排除标准
- •Corrected Visual Acuity lower than 5/10
- •Other conditions leading to oscillopsia or ataxia
- •Oculomotor palsy, ocular instability in primary position
- •Cervical rachis pathology with instability
- •Cochlear Implants
- •Non-stabilized medical disease
- •Pregnant women
- •Patients under tutelage
结局指标
主要结局
Frequency of covert-saccades
时间窗: Day 0
Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100.
次要结局
- Dynamic visual acuity(day 0)
- Quality of life assessed with the Dizziness Handicap Inventory(Day 0)
- Oscillopsia severity questionnaire score(day 0)
- Latency of covert-saccades(Day 0)