Respiratory System Compliance Guided Tidal Volume in Moderate to Severe ARDS Patients: A Multicenter Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 242
- 试验地点
- 1
- 主要终点
- the effects of tidal volume guided by respiratory system compliance on mortality in patients suffering from ARDS
研究概览
简要总结
The Acute Respiratory Distress Syndrome (ARDS) is one of common clinical critically diseases. In the United States, the incidence of ARDS reaches 31%, which is one of the main causes of death in patients. There is no unified treatment process for ARDS currently and the treatment measures are not yet standardized, so the standardization of ARDS treatment processes is needed to reduce mortality in patients. Following the evidence-based medicine principles and six-step treatment standards of ARDS, this study uses the method of multi-center randomized controlled clinical trials to evaluate the standardized treatment process of ARDS, which provides the basis for the standardized treatment of ARDS.
详细描述
From September 1st 2012 to September 30th 2014, all ARDS patients admitted to the ICUs will be enrolled. The demographic characteristics, diagnosis, formerly medical history, Ventilator indications, Ventilator data, other respiratory treatments, weaning outcome and 28 day mortality will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥ 18 years
- •admitted to the ICU
- •according to the diagnostic criteria of ARDS Berlin definition，admit patients with severe ARDS
排除标准
- •age <18 years old
- •be expected to die within 24 hours
- •end-stage malignancies
- •be participating in other studies, which may affect the results of this study
- •DNI (do not intubation) and DNR (do not recovery) patients
- •family members do not agree to sign an informed consent
结局指标
主要结局
the effects of tidal volume guided by respiratory system compliance on mortality in patients suffering from ARDS
时间窗: 28-days
次要结局
未报告次要终点
研究者
Chun Pan
physician, Zhongda Hospital
Southeast University, China