Cortical Excitability Assessment of Pharmacoresistant Focal Epilepsy Using Direct Electrical Stimulation During Stereo-electroencephalography
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Presence of a significant difference between the evoked responses to paired pulses cortical electrical stimulation of epileptogenic zone cortex and of normal cortex
研究概览
简要总结
The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG). Cortical direct electrical stimulation (DES) is commonly used during SEEG for functional mapping or to induce seizure.
However, the recording of seizures is sometimes insufficient to circumscribe the EZ and development of new biomarkers is necessary.
The cortex within the EZ is thought to be hyperexcitable. The "paired pulses" paradigm, using transcranial magnetic stimulation (TMS), allows determining the hemispheric cortical excitability level. The investigators hypothesize that paired pulses DES during SEEG could provide useful information for EZ identification.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18 years old
- •Pharmacoresistant focal epilepsy patients undergoing a stereo-electroencephalographic recording
- •Provide written consent to the study after receiving clear information
- •Be a beneficiary or member of health insurance plan
排除标准
- •Patient with contraindication for MRI scanning
- •Pregnancy
- •Prohibition on participation in other research, apart from any other non-interventional research
研究组 & 干预措施
paired pulses cortical electrical stimulation
干预措施: paired pulses cortical electrical stimulation (Other)
结局指标
主要结局
Presence of a significant difference between the evoked responses to paired pulses cortical electrical stimulation of epileptogenic zone cortex and of normal cortex
时间窗: between Day 7 and 21 (End of the stereoelectroencephalographic recordings)
Low frequency single pulse electrical stimulation induces several cortico-cortical electroencephalographic responses: early-physiological and/or late-pathological. We expect different paired pulses modulation of those responses according the excitability level of the stimulated cortex (in terms of latency, amplitude, surface, frequency power)
次要结局
- Presence of a difference between transcranial magnetic paired pulses stimulations and intracranial paired pulses cortical direct electrical stimulations(Between Day 7 and 21 (End of the stereoelectroencephalographic recordings))
- Presence of a difference of responses patterns between anatomic regions and/or lesion type(between Day 7 and 21 (End of the stereoelectroencephalographic recordings ))