Associations Between Dietary Pattern Adherence, LDL Aggregation, and Cardiometabolic Health: A Cross-sectional Analysis.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- LDL aggregation susceptibility
研究概览
简要总结
This study aims to investigate the extent to which vegan or plant-based, omnivorous, and carnivore dietary patterns affect LDL aggregation susceptibility (the affinity for LDL cholesterol particles to clump together in the blood), which may promote plaque build-up in arteries. Using a cross-sectional mixed-methods design, the study will measure LDL aggregation, blood lipids, and other metabolic biomarkers in individuals following these diets, and combine these data with dietary and behavioural information to examine links with cardiovascular and metabolic health.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 25-60 years.
- •BMI range (18.5-29.9 kg/m²).
- •Following one of the specified dietary patterns (vegan/plant-based, carnivore, or omnivorous) for a minimum of 6 months.
- •Self-identified as health-focused (i.e., intentionally following the diet for perceived health benefits).
排除标准
- •BMI outside the stated range (<18.5 or ≥30 kg/m²).
- •Use of lipid-lowering medications or supplements that may interfere with LDL levels.
- •Pregnancy or breastfeeding.
- •Any significant deviation from the specified diet within the last month.
研究组 & 干预措施
Vegan or plant-based diet
Individuals who identify as adhering to a vegan or plant-based diet habitually for a minimum period of six months.
Carnivore diet
Individuals who identify as adhering to a carnivore diet composed exclusively of animal-based products habitually for a minimum period of six months.
Omnivore diet
Individuals who identify as adhering to an omnivorous (animal and plant-based) diet habitually for a minimum period of six months.
结局指标
主要结局
LDL aggregation susceptibility
时间窗: Baseline upon enrollment.
To measure changes in how easily LDL cholesterol particles 'clump' together in the blood vessels from baseline to post-intervention, assessed via plasma lipid and lipoprotein analysis.
次要结局
- Plasma lipid and lipoprotein profile(Baseline upon enrollment.)
- Lipoprotein particle size(Baseline upon enrollment.)
研究者
Megan Wilson
Principal Investigator
Liverpool John Moores University