Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor Alpha Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Endocan levels
研究概览
简要总结
The primer aim of the study was to determine serum and gingival crevicular fluid (GCF) endocan levels in periodontal diseases pathogenesis supported with vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) levels.
详细描述
The study consist of three groups: periodontally healthy individuals (group 1; n = 20), individuals with generalized chronic periodontitis (group 2; n = 20), the same patients with chronic periodontitis after they had been treated with scaling and root planing (SRP) were considered as Group 3. Clinical measurements were recorded; GCF and serum samples were obtained from each participant before and 6 weeks after therapy. Endocan, VEGF-A and TNF-α levels were measured by enzyme-linked immunosorbent assay.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No bone and attachment loss,
- •GI=0, PPD≤3mm, CAL≤3mm
- •Systematically healthy patients
- •Group 2 Inclusion Criteria:
- •GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
- •Systematically healthy patients
排除标准
- •Aggressive Periodontitis,
- •Oral pathologies,
- •Patients with any other systemic diseases,
- •Pregnant women and those in the lactation period,
- •Patients with smoking habit and taking medication
- •Patients received periodontal therapy in last 6 months
结局指标
主要结局
Endocan levels
时间窗: 6 weeks
Change after periodontal treatment
次要结局
- TNF-alpha levels(6 weeks)
- VEGF levels(6 weeks)
研究者
ÇİĞDEM COŞKUN TÜRER
Dr.
Bulent Ecevit University