Study of Molecular-genetic Profile of Thyroid Nodules
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 主要终点
- Molecular profile of thyroid nodules
研究概览
简要总结
Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. Obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.
详细描述
This is an non-randomised retrospective study consisting of 2 parts. Part A. Histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of Belarusian population.
Part B. Fixed cytological smears of indeterminate thyroid nodules (categories III, IV and V according to Bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients operated on for malignant and benign thyroid tumors. Age is greater than or equal to 18 years old.
排除标准
- 未提供
结局指标
主要结局
Molecular profile of thyroid nodules
时间窗: 2 years
To develop a molecular profile of thyroid nodules that will allow to distinguish benign from malignant tumor
次要结局
未报告次要终点
研究者
Siarhei Yakubouski
MD PhD Assistant Professor
Belarusian State Medical University