Serum Adiponectin Concentration, Activity and Isoforms in Chinese Population and Its Correlation to Cardiovascular and Cerebrovascular Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30,000
- 试验地点
- 1
- 主要终点
- Number of Participants with major adverse events
研究概览
简要总结
Adiponectin (Ad) is an abundant protein in human body, and reports have shown that it act as a novel risk factor for brain and heart ischemia injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to these diseases.
详细描述
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes, anti-inflammatory, vascular protective, and anti-ischemic properties. Since its 1995 discovery, Ad has garnered considerable attention for its role in diabetic and cardiovascular pathology. Clinical observations have demonstrated the association of hypoadiponectinemia in patients with obesity, cardiovascular disease, and insulin resistance. There is growing evidence supporting Ad can act as a novel risk factor for cardiovascular and cerebrovascular injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to cardiovascular and cerebrovascular diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •available for 5 years of follow-up study
排除标准
- •Death caused other than cardiovascular and cerebralvascular diseases till the study ends
- •Floating Population
- •Pregnancy, lactation, or child bearing women
- •Active hepatic disease or hepatic dysfunction, or AST/ALT > 1.5UNL
- •Severe renal dysfunction(Scr > 3 mg/dl or 264μmol/L)
- •Patients with any condition which, in the investigator's judgment, might increase the risk to the subject for any adverse event or abnormal laboratory finding
结局指标
主要结局
Number of Participants with major adverse events
时间窗: 5 years
Major adverse events included but were not limited to death during the study caused by cardiovascular events or cerebrovascular events.
次要结局
- serum adiponectin concentration, activity and isoforms(5 years)
- blood routine, glucose and lipid profile; ECG;(5 years)