Effectiveness of verapamil in patients with carbamazepine-resistant epilepsy - Verapamil in epilepsy patients

Stichting Epilepsie Instellingen Nederland0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•- patients aged 18 years and older with a history of localization-related epilepsy of at least 2 years;
•- epilepsy not controlled despite the (previous) use of two or more antiepileptic drugs;
•- current use of carbamazepine as an antiepileptic drug, with the possible addition of no more than one other antiepileptic drug;
•- seizure frequency of at least 2 seizures per month;
•- AED serum levels in therapeutic range

•- There was no or an uncertain diagnosis of epilepsy, based on clinical history, seizure description and/or EEG registration.
•- progressive neurological disease
•- cardiac disease (heart failure; 2nd or 3rd degree atrioventricular block; sick sinus syndrome; Wolf-Parkinson-White syndrome; sinus bradycardia)
•- hypotension (defined as lower systolic pressure than 100 mm Hg and/or lower diastolic prerssure than 70 mm Hg)
•- pregnancy

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