Comparison of effect of intraperitoneal versus intravenous dexamethasone on postoperative nausea, and vomiting after laparoscopic cholecystectomy: A prospective, randomised, double blinded study

SUMMARY:

Proposed topic of research : COMPARISON OF EFFECT OF INTRAPERITONEAL VERSUS INTRAVENOUS DEXAMETHASONE ON POSTOPERATIVE NAUSEA, AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE, RANDOMISED, DOUBLE BLINDED STUDY.

 **Objective of research:**Comparison of efficacy of Intraperitoneal Dexamethasone with Intravenous Dexamethasone in preventing Post operative nausea & vomiting.**Background of research:**Despite all of the benefits provided by laparoscopic cholecystectomy, the Post operative nausea & vomiting is the common & distressful side effect of laparoscopic surgeries. It can negatively affect patient dissatisfaction; readmission & prolonged hospital stay and  increased medical costs. Multimodal approaches are being considered for prophylaxis of post operative nausea & vomiting. Intravenous Dexamethasone reduces post operative nausea & vomiting after laparoscopic surgeries. In this study we aim to find out if Intraperitoneal Dexamethasone would work better than Intravenous  Dexamethasone to reduce post operative nausea & vomiting following laparoscopic cholecystectomy in adult female patients.

 **Methodology:**It is a hospital based prospective, randomized, double blinded, study on adult female patients undergoing laparoscopic cholecystectomy under general anaesthesia in surgery OT of Midnapore Medical College and Hospital. A total of  100 patients will be selected randomly in two groups where one group will Receive prophylactic dexamethasone 8mg IV, the second group will receive Dexamethasone 8mg IP.  Anaesthetic and surgical management will be standardized in each group. The required parameters will be monitored in the intraoperative and postoperative period up to 24 hours postoperative period  .

***Expected outcome of proposed study:***We are expecting that incidence & severity of PONV will significantly decrease in the group intraperitoneal Dexamethasone group following laparoscopic cholecystectomy.