NCT05543291招募中不适用
Multi-omics Analysis of Chronic Kidney Disease
Shanghai 10th People's Hospital1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2022年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism
研究概览
简要总结
Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled
排除标准
- •Age<18 years.
- •Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy.
- •Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.
结局指标
主要结局
Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism
时间窗: baseline
Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression
次要结局
未报告次要终点
研究者
Ai Peng
Shanghai tenth People's Hospital
Shanghai 10th People's Hospital
研究点 (1)
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