Diyarbakir Women's and Children's Diseases Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- CTRP 9 level in preeclamptic pregnancies
研究概览
简要总结
The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric oxide synthesis (eNOS). The aim of this study was to investigate CTRP-9 levels in pregnant women with preeclampsia.
详细描述
The most important reason for the development of preeclampsia is the problem of trophoblastinvasion and consequent formation and development of placenta is not healthy
Cytokines are regulatory molecules that have effects on cell functions.Cytokines are molecules that also regulate endothelial functions. Placenta formation and widespread endothelial damage are under the influence of cytokines.
Therefore, there may be important links between impairment or imbalance in cytokine release and function and the formation of preeclampsia.Nitric oxide (NO) is a biologic enzyme that is synthesized by nitric oxide synthase (NOS) from the amino acid of L-arginine and exists in all mammals.
e(NOS) is the three isoforms of NO. It is known that NO is a major vasodilator of pregnancy, inhibiting platelet and leukocyte aggregation.There was a decrease in NO levels in preeclamptic patients.
The CqP / TNF Binding Protein (CTRP) family consists of 15 members, and is synthesized in many organs outside the body of fat.CTRP9 is predominantly excreted in fat tissue, and levels in circulation are reduced in patients with diabetes and obesity.Many studies have shown that CTRP9 exerts beneficial effects on metabolic and cardiovascular homeostasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 15 Years 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women who are ages 15-40
- •BMI ≥35 kg/m2 and BMI<25 KG/m2 pregnants
- •The clinical diagnosis of preeclampsia will follow the current criteria outlined by ACOG 10
- •> 20 th weeks of pregnancy
排除标准
- •A previously known chronic metabolic disease (diabetes, pregestational dyslipidemia, hypertension,)
- •collagen vascular diseases,
- •inflammatory bowel disease
- •chronic inflammatory conditions,
研究组 & 干预措施
preeclamptic obese pregnancy
CTRP 9 level will be assessed by 40 obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.
干预措施: Blood test (Diagnostic Test)
preeclamptic non-obese pregnancy
CTRP 9 level will be assessed by 40 non-obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.
干预措施: Blood test (Diagnostic Test)
normal pregnancy
CTRP 9 level will be assessed by 40 normal gestational ELISA methods
干预措施: Blood test (Diagnostic Test)
结局指标
主要结局
CTRP 9 level in preeclamptic pregnancies
时间窗: 3 months
Blood samples were taken from patients with preeclampsia. The diagnosis was made when the arterial blood pressure was above 140/90 mm / Hg within 6 hours and was accompanied by proteinuria (\> 300 milligrams in a sample) with high blood pressure and number of patients with proteinuria (ACOG criteria)
次要结局
未报告次要终点
研究者
Şerif AKSİN
specialist doctor
Diyarbakir Women's and Children's Diseases Hospital