NL-OMON54174招募中不适用
euroinflammation in frontotemporal lobar degeneration: a multimodal biomarker study - Neuroinflammation in FTLD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 110
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Ability to undergo MRI scanning
- •- For probable FTLD-tau: a clinical diagnosis of PSP, CBS or nfvPPA, or any
- •clinical FTLD spectrum diagnosis with a proven MAPT mutation
- •- For probable FTLD-TDP: a clinical diagnosis of svPPA or any clinical FTLD
- •spectrum diagnosis with a proven GRN mutation or C9orf72 repeat expansion
- •- For presymptomatic mutation carriers: a MAPT mutation, GRN mutation or a
- •C9orf72 mutation withouth clinical sign of a FTLD spectrum phenotype (CDR 0)
- •- For control subjects: no known neurological or psychiatric disorder
排除标准
- •- Other neurological or psychiatric disorder that may affect cognitive
- •functions, such as a brain tumour, multiple sclerosis or drug or alcohol abuse
- •or use of psycho-active medications
- •- CSF profile (β-amyloid, p-tau, t-tau) suggestive of AD pathology
- •- Clinical dementia Rating Scale (CDR) score >1
- •- Contra-indication to undergo MRI
- •- Contra-indication to undergo lumbar puncture
研究者
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