Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Grading of cough reaction
研究概览
简要总结
Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective endotracheal intubation under general anesthesia.
- •Operation time < 3 h.
- •ASA grade I or II.
- •Age 18~65 years old.
排除标准
- •Throat and neck surgery.
- •Those assessed to have a high risk of reflux aspiration.
- •Difficulty intubation.
- •History of snoring before surgery.
- •Recent respiratory illness such as chronic cough.
- •Previous airway hyperresponsiveness, such as asthma.
- •recent use of cough suppressants.
- •Patients with severe heart, liver and kidney diseases.
结局指标
主要结局
Grading of cough reaction
时间窗: During extubation procedure
Grading of cough reactions
Change in Blood pressure
时间窗: Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation
Hemodynamics
Change in Heart rate
时间窗: Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation
Hemodynamics
次要结局
- Adverse reactions(Within 24 hours after removal of the endotracheal tube)
研究者
Zhuan Zhang
Principal Investigator
Yangzhou University