NCT01640444已完成2 期
Randomized Phase II Study to Explore the Influence of BRAF and PIK3K Status on the Efficacy of FOLFIRI Plus Bevacizumab or Cetuximab, as First Line Therapy of Patients With RAS Wild-type Metastatic Colorectal Carcinoma and < 3 Circulating Tumor Cells
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)1 个研究点 分布在 1 个国家目标入组 240 人开始时间: 2012年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- progression free survival (PFS)
研究概览
简要总结
The purpose of the study is to explore the influence of BRAF and PIK3K status on the efficacy of FOLFIRI plus Bevacizumab or Cetuximab, as first line therapy of patients with RAS wild-type metastatic colorectal carcinoma and < 3 circulating tumor cells
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient's Informed consent in written.
- •Age between 18-70 years old.
- •Life expectancy of at least 3 months.
- •Histological confirmation of adenocarcinoma of the colon or rectum.
- •Sample of tumour tissue available for evaluation of genes RAS, BRAF and PI3K. To be included in the study patients should present < 3 CTC in peripheral blood and RAS wild-type present in the sample of tumor tissue.
- •Measurable metastatic stage IV disease with at least 1 measurable metastatic lesion following RECIST criteria v 1.1 (non suitable for radical surgery at the inclusion time).
- •Prior radiotherapy is allowed but must be completed at least 4 weeks before randomization (if applicable).
- •Adequate bone marrow, liver and renal function.
- •Women of childbearing potential must have a negative serum or urine pregnancy test. Postmenopausal women must have been amenorrheic for at least 12 months.Both men and women participating in this study must use adequate contraception.
- •Subject must have the ability, in the opinion of the investigator, to comply with all the study procedures and follow-up examinations.
排除标准
- •Previous chemotherapy for metastatic disease.
- •Prior treatment with Bevacizumab, or EGFR inhibitors
- •Any anticancer treatment (chemotherapy, hormonal treatment, radiation treatment, surgery , immunotherapy, biologic therapy or tumour embolization) within 4 weeks before randomization.
- •Use of any investigational drug within 4 weeks before start the treatment.
- •Clinical or radiographic evidence of brain metastasis.
- •Uncontrolled hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg on repeated measurement) despite optimal medical management.
- •Previous history of hypertensive encephalopathy or hypertensive crises.
- •Current or history of peripheral neuropathy > or equal to 1 NCICTCAE.
- •Patients classified as fragile according to criteria listed in the protocol.
- •Significant cardiovascular disease (e.g. AVC, myocardial infarction, within 6 months before randomization). Unstable angina, congestive heart failure New York Heart Association (NYHA) ≥ class II, arrhythmia that requires treatment within 3 months before randomization.
- •Significant vascular disease (e.g. aortic aneurism requiring surgical intervention, pulmonary embolic, peripheral arterial thrombosis) within 6 months before randomization.
- •Previous history of significant haemorrhage /severe, within 1 month before randomization.
- •Major surgery, open surgical biopsy or significant traumatic injury within 4 weeks before randomization.
- •Large bore needle biopsy of a major organ within 14 days before randomization. Placement of central venous access port > or equal to 7 days before randomization is permitted.
- •Evidence or history of bleeding diathesis or coagulopathy.
- •INR >1.5 within 14 days prior to starting study treatment. EXEMPTION: patients on full anticoagulation must have an in-range INR[usually between 2-3]. Any anticoagulation therapy must be at stable dosing prior to enrolment.
- •History of previous abdominal fistula or gastrointestinal perforation within 6 months before randomization.
- •Serious non-healing wound, ulcer or bone fracture.
- •Acute or sub-acute of intestinal occlusion or history of intestinal inflammatory disease.
- •History of uncontrolled convulsive crises.
- •History of pulmonary fibrosis, acute lung disease or interstitial pneumonia.
- •Chronic, actual o recent use (10 days prior first drug administration) of acetylsalicylic acic (aspirin) > 325 mg/day or clopidogrel (75mg/day) or other treatments that can cause gastrointestinal ulcer (low-dose aspirin is permitted < or equal to 325 mg/day).
- •Urinary protein excretion > or equal to 2+ (dipstick). If > or equal 2 g proteinuria is detected with dipstick, a 24-hour period urine test will be performed and the result should be < or equal to 1 g/24 hours to permit the inclusion of the patient in the clinical trial
- •Known human immunodeficiency virus infection or chronic hepatitis B or C infection or other uncontrolled, severe concurrent infection .
- •Current infection > or equal to Grade 2 (NCI-CTCAE).
- •Any previous or concurrent cancer different to colorectal carcinoma within 5 years before to start the treatment. Subjects with successfully treated, non-invasive cancers, including cervical cancer in situ, basal cell carcinoma will be allowed to participate in the clinical trial. Or those cancer treated with curative intention without disease evidence in the last 5 years at least
- •Known or suspected allergy or hypersensitivity to any component of bevacizumab, cetuximab, irinotecan, or 5-FU/LV.
- •Any medical, psychological, or social condition that may interfere with the subject's participation in the study or evaluation of the study results.
- •Any psychological, familial or geographic situation that interferes in the adequate follow-up and adherence to the study protocol.
- •Women who are pregnant or breast-feeding.
研究组 & 干预措施
A
Experimental
FOLFIRI+bevacizumab
干预措施: FOLFIRI + bevacizumab (Drug)
B
Experimental
FOLFIRI + cetuximab
干预措施: FOLFIRI + cetuximab (Drug)
结局指标
主要结局
progression free survival (PFS)
时间窗: 5 years
次要结局
- Response rate (RR)(5 years)
- Radical Resection (R0) surgery rate(5 years)
- CTC count basal and correlate to PFS, OS, RR(5 years)
- Overall survival (OS)(5 years)
- Adverse events(5 years)
- Correlation of molecular status of bio markers related to the cellular and tumoral reproduction and/or mode of action and clinical anti-tumour activity outcome ( PFS, OS, RR)(5 years)
研究者
研究点 (1)
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