Spatially Resolved Transcriptomics Reveals Phenotype-specific Molecular Signatures in Complex Regional Pain Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Numerical Rating Scale (NRS)
研究概览
简要总结
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
详细描述
Participants who meet the diagnostic criteria for CRPS, aged 19~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).
Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets the Budapest diagnostic criteria
- •Consents to participation in this study
- •Aged between 19 and 80 years old
- •Symptoms and/or signs of sensory, vasomotor, and sudomotor changes
排除标准
- •Who do not agree to participate in this study
- •Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)
结局指标
主要结局
Numerical Rating Scale (NRS)
时间窗: At the time of biopsy
Intensity of pain (now, weekly avarege, weekly maximum)
Thermography
时间窗: At the time of diagnosis
Thermography of the involved limb
Quantitative Sensory Testing (QST)
时间窗: At the time of diagnosis
Vibration Detection Threshold (VDT), Cold Detection Threshold (CDT)
次要结局
未报告次要终点
研究者
Jeeyoun Moon
Professor
Seoul National University