NCT01523691已完成不适用
Repeating Patterns of Sleep Restriction and Recovery - do we Get Used to it?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- stress-related markers
研究概览
简要总结
Goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI) between 18.5 and 30 kg/m2
- •For female participants: regular menstrual cycles
- •Daily sleep duration in the normal range
- •Blood chemistry in the normal range
排除标准
- •Active infection/disease
- •History of psychiatric, neurological, pain-related, immune, or cardiovascular disease; significant allergy
- •Pregnant/nursing
- •Respiratory disturbance index of >5 events/hour on polysomnographic sleep study, leg movements with arousal >10/hour; sleep efficiency <80%
- •Regular medication use other than oral contraceptives
- •Donation of blood or platelets 3 month prior to or in-between study arms
结局指标
主要结局
stress-related markers
时间窗: Participants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.
cortisol, ACTH, norepinephrine, IL-6, COX in blood/urine, among others
次要结局
- subjective stress-related markers(Participants will be followed for the duration of hospital stay, an axpected average of 2 x 25 days.)
研究者
Monika Haack
Assistant Professor of Neurology
Beth Israel Deaconess Medical Center
研究点 (2)
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