Genomic Evolution of Metastasis in Gastric Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Genetic and epigenetic changes of the tumor
研究概览
简要总结
The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.
详细描述
Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Metastasis is the leading cause of death in gastric cancer patients, with median overall survival of less than 1 year. Currently, there is no effective treatment because the molecular mechanism of metastasis remains unclear. The aim of this study is to use advanced NGS technologies to dissect the genomic changes (genetic, epigenetic and transcriptional changes) of the primary tumor and associated metastatic sites of the same patients. With that, the investigators can reconstruct the clonal evolution from primary tumor to metastasis, identify key pathways governing metastasis development that can be targeted for future therapeutic development.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female patients aged 18 years and older
- •Histologically proven primary gastric adenocarcinoma and clinical evidence of metastasis (N1-3M1)
- •Biopsies can be taken at multiple sites
- •No known other concomitant cancer diagnosis
- •Signed informed consent
排除标准
- •Gastric adnocarcinoma cannot be confirmed primary
- •Unable to undergo biopsy or surgery
结局指标
主要结局
Genetic and epigenetic changes of the tumor
时间窗: 3 months after surgery
Ultra-deep NGS of the primary tumor and associated metastatic sites from the same patients to identify mechanism governing metastasis development
次要结局
未报告次要终点