Patient Adherence to Prescribed Therapy in Ulcerative Colitis: an Investigation of Barriers & Methods of Improvement.
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 80
- 主要终点
- Levels of patient adherence to therapy will be assessed in two ways:
研究概览
简要总结
Ulcerative Colitis is associated with a significantly increased risk of colorectal cancer. This risk can be reduced through regular medication with 5ASA compounds. Their effectiveness however is limited by poor adherence to the treatment protocols by many patients.
The hypothesis which underlies this proposal is that if the factors responsible for poor compliance can be identified, interventions could be developed which would help to overcome the barriers which exist in individual patients. These interventions would be based on the reasons for non-adherence, specifically tailored to the needs of the individual. As a result such interventions will improve patients' adherence with prescribed 5ASA and therefore reduce the relapses of the disease and a cancer risk.
详细描述
Poor adherence to treatment is well recognised and significantly contributes to treatment failures. In ulcerative colitis it may be associated with an increased risk of colorectal cancer. Estimates for non-adherence range from 15% to 93% with an average of around a third of patients failing to adhere to their recommended therapeutic regimen.
The study aims to evaluate a wide-ranging approach to reducing poor adherence, which is based on factors associated with non-adherence and involves the patient in choosing interventions.
The effectiveness of the overall intervention will be assessed through a randomised controlled trial comparing intervention against standard care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients aged 18-
- •Those in whom a diagnosis of ulcerative colitis is based on histological confirmation of the disease.
- •Patients who are on daily maintenance therapy with 5 ASA medication.
- •Patients who have read the information leaflet and voluntarily given informed consent.
排除标准
- •Those aged under 18 years old.
- •Those with a diagnosis of Crohn's disease.
- •Patients not on regular 5ASA compound as maintenance therapy.
- •Patients unable to give informed consent.
- •Patients who do not wish to participate in the study.
结局指标
主要结局
Levels of patient adherence to therapy will be assessed in two ways:
时间窗: 1 year
through pill counts and measurement of salicylate levels in urine samples.
时间窗: 1 year
次要结局
- Quantitative data will be collected through feedback from patients.(1 year)