Interest in the Implementation of a Systematic Protocol for the Dosage of the S100B Protein in the Reduction of the Use of Brain Scans for Patients With Mild Traumatic Brain Injury in the Emergency Room of Douai Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 258
- 试验地点
- 1
- 主要终点
- Measurement of the S100B protein to the emergency department of the Douai hospital
研究概览
简要总结
The main objective is to evaluate the feasibility and interest of setting up a protocol for the systematic measurement of the S100B protein in patients with mild traumatic brain injury admitted to the emergency room of Douai hospital in order to reduce the number of unnecessary brain scans. The main evaluation criterion is the percentage of patients admitted to the emergency department of Douai hospital for mild traumatic brain injury, whose protocol for the systematic measurement of the S100B protein would make it possible to avoid the realization of a brain scans for patients with a protein assay S100B ≤ 0.10 µg/L, carried out within 3h of the onset of MCT.
The systematic dosage of the S100B protein in the context of mild traumatic brain injury still does not appear in the recommendations for good practice in 2021. This study will contribute to the reflection on the use of the S100B protein in the development of new recommendations for good practice of mild traumatic brain injury support.
详细描述
This is an observational, prospective, monocentric study. This study concerns patients over 18 years of age treated in the emergency room of Douai hospital for mild traumatic brain injury treated within 3 hours following the head trauma according to the Jéle et al classification and who have no history of melanoma.
After verification of the patient's eligibility criteria for participation in this study, information relating to the research in order to obtain their authorization to participate in the research.
Once authorization has been obtained, an additional tube of blood is collected when drawing blood samples from the patient as part of their care.
Data are collected and a brain scan performed during the treatment and this is used to fill in the research data collection sheet.
The data used in this research come from the direct questioning of patients. They are recorded on a paper form or in a computerized medical record.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged over 18 years having had a traumatic brain within 3h with Glasgow >13
- •Patients having made a mild traumatic brain injury according to the Jehlé and Al classification:
- •Either, amnesia of the facts > 30 minutes before the MCT (retrograde amnesia) or either, loss of consciousness or amnesia associated with one of the following mechanisms :
- •Either pedestrian knocked down by a vehicle
- •Either patients ejected from a vehicle
- •Either fall from a height > 1 meter
- •Either Age > 65 years old
- •Either patients under anti platelet aggregation
- •Patients informed about the study
排除标准
- •Patients with a history of melanoma or in melanoma follow-up care
- •Patients under guardianship or curatorship
- •Patients deprived of liberty (prisoner)
- •Patients not meeting MCT criteria
- •Refusal to participate in the study
- •Refusal to perform brain scan
- •Glasgow Rating <13
- •Unknown MCT Time
- •Unclear patient history
- •Polytraumatized
- •Congenital or acquired coagulopathy
结局指标
主要结局
Measurement of the S100B protein to the emergency department of the Douai hospital
时间窗: At 3 hours after MCT
Percentage of patients admitted to the emergency department of the Douai hospital for MCT, whose protocol for the systematic measurement of the S100B protein would make it possible to avoid the realization of a brain scan for patients with a protein assay s100B ≤ 0.10 µg/L, carried out within 3h of the onset of MCT.
次要结局
- Measurement of the S100B protein for a threshold ≤0.10 µg//l(At 3 hours after MCT)
- Length of hospital stay(Immediatly after the procedure)