Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Correlation of fMRI and EEG functional connectivity.
研究概览
简要总结
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.
详细描述
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.
The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.
Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).
EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.
For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or females aged 18 years or older.
- •Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
- •Able to cooperate in an EEG evaluation
- •Can read and sign the informed consent.
排除标准
- •Any scalp/bone abnormality incompatible with the EEG electrodes
- •Any known allergy to metals.
- •Inability to cooperate with simple instructions.
- •Inability to read and sign the informed consent.
研究组 & 干预措施
Electroencephalography (EEG)
EEG excels in capturing rapid changes in neural activity, making it ideal for investigating the dynamic nature of brain networks. It can detect millisecond-level fluctuations in electrical brain signals, allowing precise timing of neural events and interactions between brain regions.
干预措施: EEG (Diagnostic Test)
结局指标
主要结局
Correlation of fMRI and EEG functional connectivity.
时间窗: The expected study duration is approximately 24 months (first patient in to last patient out)
Examines how brain connectivity patterns measured by fMRI (blood-flow activity) relate to connectivity patterns measured by EEG (electrical activity).
次要结局
- Correlation between EEG to anatomical MRI findings(The expected study duration is approximately 24 months (first patient in to last patient out))
- Correlation between EEG to clinical diagnosis, cognitive and physical parameters.(The expected study duration is approximately 24 months (first patient in to last patient out))
研究者
Shay Efrati
Professor
Assaf-Harofeh Medical Center