Effects of Alternate Day Fasting and Exercise on Body Weight, Visceral Fat, and Metabolic Parameters in Overweight or Obese Adults: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- Change in body weight
研究概览
简要总结
Alternate day fasting is known to be helpful to control weight and have a positive effect on insulin resistance and cardiovascular risk factors. However, there have been no studies on weight reduction program combining alternate day fasting with exercise which preserves lean mass in Korea. The purpose of this randomized clinical trial is to examine the effects of alternate day fasting and exercise on weight reduction, visceral fat, and metabolic parameters in overweight or obese adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 20-65 years
- •Body mass index (BMI) more than 23.0 kg/m² (overweight or obese for Asian populations, according to the World Health Organization)
排除标准
- •Participants with weight gain more than 5kg in the last 3 months
- •Participants with history of bariatric surgery
- •Participants with secondary obesity, such as hypothyroidism
- •Participants with uncontrolled hypertension or type 1 diabetes
- •Participants who are taking anti-diabetic medications due to type 2 diabetes
- •Participants with hepatic disease (AST or ALT ≥200 mg/dL)
- •Participants with renal disease (serum creatinine ≥2.0 mg/dL)
- •Participants with pancreatitis or related disorders
- •Participants with acute infectious diseases (i.e., pneumonia, acute enteritis, or urinary infection)
- •Participants with chronic inflammatory diseases (i.e., rheumatoid arthritis, or lupus)
- •Participants with overeating behavior
- •Participants with history of cardiovascular diseases
- •Participants with history of cancer
- •Participants who are taking anti-obesity, anti-diabetic, diuretic, central-nervous system, antidepressant, antipsychotic, or steroid medications
- •Pregnant or lactating women
- •Participants who intake more than 30 g of alcohol daily
- •Night-time or shift-work workers
- •Participants with chronic malabsorption syndrome or cholestasis
- •Participants with other medical conditions that would preclude subjects from participating in exercise and physical test
研究组 & 干预措施
Alternate Day Fasting and Exercise
干预措施: Alternate Day Fasting (Behavioral)
Alternate Day Fasting and Exercise
干预措施: Exercise (Behavioral)
Alternate Day Fasting
干预措施: Alternate Day Fasting (Behavioral)
Exercise
干预措施: Exercise (Behavioral)
Control
regular eating and exercise habits for 8 weeks
结局指标
主要结局
Change in body weight
时间窗: baseline, 8 weeks
body weight (kg)
次要结局
- Change in visceral fat(baseline, 8 weeks)
- Change in fasting glucose(baseline, 8 weeks)
- Change in insulin(baseline, 8 weeks)
- Change in triglyceride(baseline, 8 weeks)
- Change in high-density lipoprotein cholesterol (HDL-cholesterol)(baseline, 8 weeks)
- Change in low-density lipoprotein cholesterol (LDL-cholesterol)(baseline, 8 weeks)
研究者
Ji-Won Lee
Associate Professor
Gangnam Severance Hospital