The Impact of Glycemic Index on Sleep and Memory Consolidation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Sleep onset latency (polysomnography)
研究概览
简要总结
The study will test whether the consumption of a low versus a high glycemic index pre-bed drink influences sleep architecture, memory consolidation, nocturnal glucose metabolism, and mood.
详细描述
Few studies have examined the impact of meal composition on sleep. Most research has focused on carbohydrate intake, although reports are sporadic and confounded by the manipulation of other macronutrients. Nonetheless, the pattern of results appears to depend on the nature of the sleep variable under investigation e.g., latency, duration, or efficiency. The study will determine whether manipulating the glycemic index of a pre-bed drink influences sleep architecture, procedural and declarative memory consolidation, nocturnal glucose metabolism, and mood.
Participants will stay in the sleep laboratory for three nights, each night separated by one week (visit 1, 2, and 3). The first night is an acclimatisation night. The same procedure will be followed on all three nights, as described below.
On the morning of each visit, a continuous glucose monitor will be set up and worn until 8pm the following evening. Participants will be asked to return to the sleep laboratory at 7pm, having fasted for five hours, and asked to consume a standardised evening meal. Several mood questionnaires will be completed throughout the evening and a polysomnography will be set up. Two memory tasks will be administered at approximately 10pm. Immediately after this, participants will consume either water (night 1), or a low glycemic index or high glycemic index drink (night 2 or 3). Participants will retire to bed at approximately 11pm and woken up between 6.30am - 8am, depending on personal preference.
In the morning, the memory tasks will be administered again, as well as two mood questionnaires. Participants will be asked to wear a Pro-Diary watch throughout the day, which measures mood and hunger. At 8pm, both the continuous glucose monitor and Pro-diary watch will be collected from the participant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
To ensure blinding of participants and researchers, a randomisation list will be produced using Statistical Package for the Social Sciences (SPSS) software by an employee of Swansea University, who is not actively involved in the study.
Blinding will be maintained by the use of encoded beverages to ensure participants, researchers, and the data analysers are unaware of the intervention. The blind will be broken only after statistical analysis of the data is complete.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male (given that the menstrual cycle may influence sleep polysomnography)
- •Good health
- •Not taking any medication known to effect sleep or metabolism
- •Normal sleep duration (i.e. between 6.5 - 9 hours of sleep per night)
- •A sleep efficiency score above 80% (Pittsburg Sleep Quality Index)
- •Normal sleep schedule (i.e. fall asleep between 10pm and 12pm)
- •No difficulty sleeping in new places
排除标准
- •Diagnosis of any physical or mental disorder e.g. diabetes, cardiovascular disorders, gastrointestinal disorders, sleep problems, epilepsy, or mood disorders
- •Unhealthy weight (BMI over 30)
- •Drink more than 300mg of caffeine per day (3 - 4 standard sized 8-oz cups)
- •Work nights or shifts
- •Smoke/vape
- •Regularly drink alcohol (>3 glasses per day)
- •Used recreational drugs within the last 6 months
- •Take part in >3 hours of vigorous exercise per week
- •Any known food allergies or intolerances
- •Nocturnal eating or regular consumption of alcohol before bed (assessed by the Meal Pattern Questionnaire)
结局指标
主要结局
Sleep onset latency (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
Onset of sleep from the time the lights are turned off.
Wake after sleep onset (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
Hours of wake time after three epochs of sleep have occurred.
Total sleep time (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
The total number of hours of sleep.
Leeds Sleep Evaluation Questionnaire
时间窗: Administered 10 - 20 minutes after waking up in the morning,
Subjective assessment of sleep quality. Scores range from 0 to 30. Higher scores indicate poorer sleep quality.
Sleep efficiency (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
Total sleep time divided by the time from lights out until awakening in the morning.
Sleep stages (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
Time spent in each sleep stage.
Arousal index (polysomnography)
时间窗: Bedtime (approx. 11.00pm) to wake time (approx 7.30am)
Number of arousals throughout the night.
次要结局
- Glucose response (continuous glucose monitor)(25 hours during night 2 and night 3 (weeks 2 and 3))
- Finger tapping task (procedural memory)(Completed at 10pm, and between 6.30 - 8am the following morning, on night 2 and night 3 (week 2 and 3).)
- Story recall task (declarative memory)(Completed at 10pm, and between 6.30 - 8am the following morning, on night 2 and night 3 (week 2 and 3).)
- Epworth Sleepiness Scale(Administered at 8pm on the evening after night 2 and night 3 (week 2 and 3).)
- Mood and hunger(Completed five times throughout the evening and twice in the morning (immediately after waking up and 20-30 minutes later) on night 2 and night 3 (week 2 and 3). .)
- Mood(Prompted from 9.30am - 5.30pm after night 2 and night 3 (week 2 and 3).)
- Actigraphy(Night 2 and night 3 (week 2 and 3).)
研究者
Dr Hayley Young
Associate Professor
Swansea University