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临床试验/NCT04246840
NCT04246840已完成不适用

Study Through Imaging of Mediastinal and Abdominopelvic Secondary Lymphoid Organs (Lymph Nodes) in Patients With Severe Combined Immunodeficiencies (SCID) Who Have Recieved Bone Narrow Allograft

Association Pour l'Aide a la Recherche en Immunologie Pediatrique1 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2020年1月13日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
18
试验地点
1
主要终点
Size of mediastinal and intraabdominal lymph nodes

研究概览

简要总结

To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago.

The goal aims to assess the development of seconday lymphoid organs given the fact that the absence of myeloablation these patients present a split chimerism between T lymphocytes and the other leucocytes. Thus, they may not be able to generate seconday lymphoid organs. Practically, whole body MRI is being used to visualise and quantify both mediastinal and intraabdominal lymph nodes. Delta will be compared with those obtained in healthy age-matched individuals. It is scheduled to include 15 patients and 15 controls.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with SCID transplanted 15-45 years ago

排除标准

  • 未提供

结局指标

主要结局

Size of mediastinal and intraabdominal lymph nodes

时间窗: 1 year

analysis by MRI

次要结局

未报告次要终点

研究者

发起方
Association Pour l'Aide a la Recherche en Immunologie Pediatrique
申办方类型
Other
责任方
Sponsor

研究点 (1)

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