Skeletal Muscle Wasting in Patients With Sepsis
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- HO-1 mRNA and protein expression, mitochondria function of musculus vastus lateralis
研究概览
简要总结
The current project was designed to examine dynamic changes in muscle wasting during sepsis. Researchers will focus the mitochondrial dysfunction of muscle cells and investigate the role of HO-1 in it. Researchers interested in identifying factors involved in the pathology of muscle wasting during sepsis.
详细描述
Rapid muscle atrophy or muscle wasting occured to septic patients.Sepsis induced muscle wasting has become a severe, frequent, and persistent complication among critically ill patients. Multiple factors including ubiquitin-proteasome system, proinflammatory cytokines and oxidative stress contribute muscle proteolysis.
It is known that heme oxygenase-1 (HO-1) possesses a variety of functions like anti-inflammatory, antioxidative and anti-apoptosis effects. In order to investigate the mechanisms under the condition, researchers are going to examine the role of HO-1 in muscle atrophy during sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •sepsis, severe sepsis, septic shock
- •clinical reason for fixation surgery of femoral fractures
排除标准
- •no informed consent
- •medical history of myopathy
- •unintended weight loss before surgery or ICU admission
- •chronic use of corticosteroids
结局指标
主要结局
HO-1 mRNA and protein expression, mitochondria function of musculus vastus lateralis
时间窗: 3 days after diagnosis
次要结局
- length of ICU stay(60 days)
- muscle myosin content(3 days after diagnosis)
- length of mechanical ventilation(60 days)
研究者
Xiaoming Deng
Chief, Professer
Changhai Hospital