ACTRN12617000243314已完成2 期
The glycaemic and hormonal effects of metformin when administered to the distal vs proximal small intestine in type 2 diabetes
niversity of Adelaide0 个研究点目标入组 10 人开始时间: 2017年2月17日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Type 2 diabetes (World Health Organisation (WHO) criteria), managed by diet only
- •Body mass index (BMI) 20 - 40 kg/m2
- •Males and post-menopausal females
- •Glycated haemoglobin (HbA1c) less than 8.5%
- •Haemoglobin above the lower limit of the normal range (ie. greater than 135g/L for men and 115g/L for women), and ferritin above the lower limit of normal (ie. greater than 30ng/mL for men and greater than 20mg/mL for women)
排除标准
- •Use of any medication that may influence gastrointestinal motor function within 48 hours or 5 half-lives of the study, specifically: opiates, anticholinergics, levodopa, clonidine, nitrates, phosphodiesterase type 5 inhibitors, sumatriptan, metoclopramide, domperidone, cisapride, tegaserod, or erythromycin
- •Evidence of drug abuse, or consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
- •History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
- •Other significant illness, including epilepsy, cardiovascular or respiratory disease
- •Impaired renal or liver function (as assessed by calculated creatinine clearance less than 90 mL/min or abnormal liver function tests (greater than 2 times upper limit of normal range))
- •Donation of blood within the previous 3 months
- •Participation in any other research studies within the previous 3 months
- •Females who are pre-menopausal
- •Inability to give informed consent
- •Participants who do not eat beef
- •Vegetarian diet
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